Additive-free coupling of bromoalkynes with secondary phosphine oxides to generate alkynylphosphine oxides in acetic anhydride
A coupling of bromoalkynes with secondary phosphine oxides was developed for the synthesis of alkynylphosphine oxides. This transformation was accomplished under additive-free conditions in acetic anhydride (Ac2O). The reaction could be furnished with mild conditions, and a wide range of secondary phosphine oxides were obtained in good yields.
- This article is part of the themed collection: Synthetic methodology in OBC