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Aldol sensor-inspired fluorescent probes for measuring protein citrullination

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Abstract

Protein citrullination is an important posttranslational modification on an arginine residue. However, high quality fluorescent probes for measuring the citrullination level and capturing citrullinated proteins are quite limited. Inspired by the similarity between acid-promoted citrulline-labeling reaction and aldol reaction, here we present “turn-on” and “turn-off” fluorescent probes for measuring citrulline levels based on the scaffold of aldol sensors. Further application of the modified probe showed great potential to simultaneously monitor and capture citrullinated peptides.

Graphical abstract: Aldol sensor-inspired fluorescent probes for measuring protein citrullination

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Article information


Submitted
24 Dec 2019
Accepted
22 Jun 2020
First published
22 Jun 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Aldol sensor-inspired fluorescent probes for measuring protein citrullination

H. Chen, H. Zhao, L. Xiang, H. Wu, Y. Liang, X. Huang and J. Zhang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02737H

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