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Visible-light-driven metal-free aerobic synthesis of highly diastereoselective phosphinoylpyrroloindoles

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Abstract

A visible-light-driven metal-free phosphorus radical mediated construction of 2-phosphinoyl-3H-pyrrolo[1,2,a]indoles is described. This mild tandem phosphinoylation/cyclization protocol utilizes air as a green oxidant and proceeds in a short span of time at room temperature with high functional group tolerance, and excellent chemo- and diastereoselectivity.

Graphical abstract: Visible-light-driven metal-free aerobic synthesis of highly diastereoselective phosphinoylpyrroloindoles

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Article information


Submitted
24 Dec 2019
Accepted
24 Jan 2020
First published
27 Jan 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Visible-light-driven metal-free aerobic synthesis of highly diastereoselective phosphinoylpyrroloindoles

R. Gorre, D. Enagandhula, S. Balasubramanian and S. M. Akondi, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02730K

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