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I2/TBHP mediated diastereoselective synthesis of spiroaziridines

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Abstract

Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.

Graphical abstract: I2/TBHP mediated diastereoselective synthesis of spiroaziridines

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Article information


Submitted
23 Dec 2019
Accepted
04 Feb 2020
First published
05 Feb 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

I2/TBHP mediated diastereoselective synthesis of spiroaziridines

K. T. Ashitha, P. P. Vinaya, A. Krishna, D. C. Vincent, R. Jalaja, S. Varughese and S. Balappa Somappa, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02711D

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