Jump to main content
Jump to site search


CuBr2-catalyzed diastereoselective allylation: total synthesis of decytospolides A and B and their C6-epimers

Author affiliations

Abstract

An efficient CuBr2-catalyzed diastereoselective allylation of a cyclic hemiacetal with allyltrimethylsilane as a nucleophile has been developed. The protocol offers a cost effective, protecting group tolerant, and operationally simple approach to 2,6-trans-disubstituted tetrahydropyran with excellent diastereoselectivity. Furthermore, the application of this methodology has been demonstrated in the total synthesis of decytospolides A and B and their C6-epimers.

Graphical abstract: CuBr2-catalyzed diastereoselective allylation: total synthesis of decytospolides A and B and their C6-epimers

Back to tab navigation

Supplementary files

Article information


Submitted
18 Dec 2019
Accepted
08 Mar 2020
First published
09 Mar 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

CuBr2-catalyzed diastereoselective allylation: total synthesis of decytospolides A and B and their C6-epimers

B. Padhi, G. S. Reddy, N. A. Mallampudi, U. M. Choudhury and D. K. Mohapatra, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02689D

Social activity

Search articles by author

Spotlight

Advertisements