Catalytic strategies towards 1,3-polyols synthesis by enantioselective cascades creating multiple alcohol functions
This review highlights the different strategies ensuring enantioselective catalyst-controlled cascades, for the rapid preparation of 1,3-polyols or 1,3-polyols precursors. These cascades enable the selective assembly of multiple substrates considerably limiting operations and waste generation. For this purpose, several mono- or bi-directional approaches have been devised allowing successive C-C bond forming events. The considerable synthetic economies these cascades enable have been demonstrated in the preparation of a wide variety of complex bioactive natural products.