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Catalytic strategies towards 1,3-polyols synthesis by enantioselective cascades creating multiple alcohol functions

Abstract

This review highlights the different strategies ensuring enantioselective catalyst-controlled cascades, for the rapid preparation of 1,3-polyols or 1,3-polyols precursors. These cascades enable the selective assembly of multiple substrates considerably limiting operations and waste generation. For this purpose, several mono- or bi-directional approaches have been devised allowing successive C-C bond forming events. The considerable synthetic economies these cascades enable have been demonstrated in the preparation of a wide variety of complex bioactive natural products.

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Article information


Submitted
17 Dec 2019
Accepted
13 Jan 2020
First published
14 Jan 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Review Article

Catalytic strategies towards 1,3-polyols synthesis by enantioselective cascades creating multiple alcohol functions

C. Sperandio, J. Rodriguez and A. Quintard, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9OB02675D

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