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External oxidant-free alkylation of quinoline and pyridine derivatives

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Abstract

A novel and efficient method for the generation of alkyl radicals and the alkylation of quinoline and pyridine derivatives under mild conditions has been developed. This strategy allows the direct alkylation of heteroaromatics in the absence of an external oxidant. A preliminary mechanistic study suggests that the present reaction probably proceeds via an intermolecular HAT process.

Graphical abstract: External oxidant-free alkylation of quinoline and pyridine derivatives

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Article information


Submitted
13 Dec 2019
Accepted
11 Feb 2020
First published
13 Feb 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

External oxidant-free alkylation of quinoline and pyridine derivatives

L. Shen, X. Gao, N. Luan, Z. Liu, J. Li, D. Zou, Y. Wu and Y. Wu, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02653C

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