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Recent advances in the direct β-C(sp2)–H functionalization of enamides

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Abstract

The direct β-C(sp2)–H functionalization of enamides has attracted increasing attention among the chemical community, due to the diverse biological and pharmaceutical activities of enamides. This review is focused on the recent advances in the direct β-C(sp2)–H functionalization of enamides, mainly including arylation, alkenylation, alkynylation, alkylation, acylation, sulfonylation, phosphorylation, and others. Additionally, mechanistic features of these transformations are also discussed.

Graphical abstract: Recent advances in the direct β-C(sp2)–H functionalization of enamides

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Article information


Submitted
13 Dec 2019
Accepted
15 Jan 2020
First published
15 Jan 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Review Article

Recent advances in the direct β-C(sp2)–H functionalization of enamides

T. Zhu, S. Xie, P. Rojsitthisak and J. Wu, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02649E

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