Recent Progress on the Total Synthesis of Marine Brominated Sesquiterpene Aplydactone
Aplydactone is a brominated sesquiterpene isolated from the sea hare Aplysia dactylomela. Structurally, it features a complex cage-like skeleton containing a highly strained tricyclic-[4.2.0.03,8]-4-decanone system. The unique structural features fascinate many synthetic chemists. In this review, the synthetic efforts of aplydactone in the last five years are summarized in two categories including nonbiomimetic synthesis and biomimetic synthesis based on the core synthetic strategy. These syntheses set a classical and instructive example for the syntheses of other marine natural products.
- This article is part of the themed collection: Total synthesis in OBC