Jump to main content
Jump to site search


Silver/palladium relay catalyzed 1,3-dipole annulation/allylation reactions to access fully substituted allyl imidazolidines

Author affiliations

Abstract

A silver/palladium relay catalyzed 1,3-dipole annulation/allylation reaction of iminoesters and Baylis–Hillman acetates for the construction of fully substituted allyl imidazolidines is reported. The reaction of both iminoesters and Baylis–Hillman acetates affords the fully substituted allyl imidazolidines in high yields and regioselectivities. The three component reaction is triggered by silver-catalyzed 1,3-dipole annulation, followed by the sequential palladium catalyzed allylation. Mechanistic studies reveal that the dual catalytic system plays a key role in the reaction. The developed methodology provides straightforward access to allyl imidazolidines under simple reaction conditions.

Graphical abstract: Silver/palladium relay catalyzed 1,3-dipole annulation/allylation reactions to access fully substituted allyl imidazolidines

Back to tab navigation

Supplementary files

Article information


Submitted
11 Dec 2019
Accepted
30 Dec 2019
First published
30 Dec 2019

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Silver/palladium relay catalyzed 1,3-dipole annulation/allylation reactions to access fully substituted allyl imidazolidines

R. Han, Y. Ding, X. Jin and E. Li, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02633A

Social activity

Search articles by author

Spotlight

Advertisements