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Photeroids A and B, unique phenol–sesquiterpene meroterpenoids from the deep-sea-derived fungus Phomopsis tersa

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Abstract

Photeroids A (1) and B (2), two structurally fascinating meroterpenoids, were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Their structures were sufficiently established by a comprehensive interpretation of the spectroscopic data, NMR spectra, and ECD calculation. Photeroids A and B represented the first phenolic sesquiterpene meroterpenoids featuring a highly fused 6/6/6/6 tetracyclic ring system derived through a rarely-occurring hetero-Diels–Alder reaction via an orthoquinone methide intermediate. Additionally, they were also evaluated for their cytotoxic activities against four human cancer cells, wherein compounds 1 and 2 exhibited moderate cytotoxic activities.

Graphical abstract: Photeroids A and B, unique phenol–sesquiterpene meroterpenoids from the deep-sea-derived fungus Phomopsis tersa

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Article information


Submitted
10 Dec 2019
Accepted
24 Dec 2019
First published
09 Jan 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Communication

Photeroids A and B, unique phenol–sesquiterpene meroterpenoids from the deep-sea-derived fungus Phomopsis tersa

S. Chen, Z. Liu, H. Tan, Y. Chen, S. Zhu, H. Liu and W. Zhang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02625H

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