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Synthetic approaches towards avibactam and other diazabicyclooctane β-lactamase inhibitors

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Abstract

Avibactam is a non β-lactam β-lactamase inhibitor that has recently been approved in association with a β-lactam antibiotic for the treatment of severe infections caused by otherwise resistant bacteria. Its therapeutic success encouraged the development of many congeners based on its particular diazabicyclooctane scaffold. This review presents a detailed overview of the synthetic strategies that have been implemented to acces these complex bicyclic compounds with a particular focus on those that are currently on the market or in clinical trials.

Graphical abstract: Synthetic approaches towards avibactam and other diazabicyclooctane β-lactamase inhibitors

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Article information


Submitted
06 Dec 2019
Accepted
13 Jan 2020
First published
13 Jan 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Review Article

Synthetic approaches towards avibactam and other diazabicyclooctane β-lactamase inhibitors

L. Peilleron and K. Cariou, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02605C

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