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Issue 7, 2020
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Synthesis of rhodium(iii)-catalyzed isoquinoline derivatives from allyl carbonates and benzimidates with hydrogen evolution

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Abstract

A novel Rh(III)-catalyzed cascade C–H activation/cyclization approach to access isoquinoline derivatives from benzimidates and available allyl carbonates with the liberation of H2 has been realized. Allyl carbonates were first used as a versatile and universal C2 synthon to synthesize this biological activity skeleton via an efficient and practical process just within 1 h.

Graphical abstract: Synthesis of rhodium(iii)-catalyzed isoquinoline derivatives from allyl carbonates and benzimidates with hydrogen evolution

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Article information


Submitted
29 Nov 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Org. Biomol. Chem., 2020,18, 1412-1416
Article type
Paper

Synthesis of rhodium(III)-catalyzed isoquinoline derivatives from allyl carbonates and benzimidates with hydrogen evolution

C. Li, H. Xu, J. Zhang, M. Liu and L. Dong, Org. Biomol. Chem., 2020, 18, 1412
DOI: 10.1039/C9OB02553G

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