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Synthesis of 3-acylindoles via copper-mediated oxidative decarbethoxylation of ethyl arylacetates

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Abstract

An efficient regioselective C-3 acylation of free indoles (N–H) has been accomplished via oxidative decarbethoxylation of easily available ethyl arylacetates using Cu(OAc)2 and KOtBu in DMSO.

Graphical abstract: Synthesis of 3-acylindoles via copper-mediated oxidative decarbethoxylation of ethyl arylacetates

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Article information


Submitted
28 Nov 2019
Accepted
03 Feb 2020
First published
03 Feb 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Synthesis of 3-acylindoles via copper-mediated oxidative decarbethoxylation of ethyl arylacetates

A. Jaiswal, A. K. Sharma and K. N. Singh, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02550B

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