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K2S2O8-HFIP synergistically promoted para-selective sp3 C–H bond diarylation of glycine esters

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Abstract

A metal-free K2S2O8-HFIP synergistically promoted double Friedel–Crafts alkylation between a glycine derivative and N-substituted aniline was developed to efficiently synthesize diarylmethane derivatives with high para-selectivity. The reaction proceeded smoothly in the absence of any metal and ligand, and exhibited a good tolerance of functional groups.

Graphical abstract: K2S2O8-HFIP synergistically promoted para-selective sp3 C–H bond diarylation of glycine esters

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Article information


Submitted
19 Nov 2019
Accepted
16 Dec 2019
First published
17 Dec 2019

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

K2S2O8-HFIP synergistically promoted para-selective sp3 C–H bond diarylation of glycine esters

Q. Xu, B. Li, Y. Ma, F. Sun, Y. Gao and N. Ye, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02489A

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