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Issue 3, 2020
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Highly selective staining and quantification of intracellular lipid droplets with a compact push–pull fluorophore based on benzothiadiazole

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Abstract

A robust lipophilic dye, based on the structures of the benzothiadiazole heterocycle, was shown to be a potent fluorescent stain for the selective imaging of lipid droplets (LDs) within both live and fixed human cells. Its small molecular framework, large Stokes shift, and vastly improved photostability over that of the current status quo, Nile Red, highlight its tremendous potential as a versatile chemical tool for facilitating LD imaging and research.

Graphical abstract: Highly selective staining and quantification of intracellular lipid droplets with a compact push–pull fluorophore based on benzothiadiazole

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Supplementary files

Article information


Submitted
18 Nov 2019
Accepted
11 Dec 2019
First published
12 Dec 2019

This article is Open Access

Org. Biomol. Chem., 2020,18, 495-499
Article type
Paper

Highly selective staining and quantification of intracellular lipid droplets with a compact push–pull fluorophore based on benzothiadiazole

S. I. Suarez, C. C. Warner, H. Brown-Harding, A. M. Thooft, B. VanVeller and J. C. Lukesh, Org. Biomol. Chem., 2020, 18, 495
DOI: 10.1039/C9OB02486G

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