Jump to main content
Jump to site search


Substituent-controlled Chemoselective Synthesis of Multi-substituted Pyridones via One-pot Three-component Cascade Reaction

Abstract

An efficient and concise one-pot strategy for the synthesis of multisubstituted pyridones via one-pot three-component cascade reaction catalyzed by Cs2CO3 under solvent-free conditions has been developed. The substituent-controlled chemoselective cycloaddition process involved steps including a Michael addition/ethanol elimination/intermolecular cyclization sequence by utilizing anilines, diethyl acetylenedicarboxylate,and diethyl ethoxymethylenemalonate. In doing so, various 2-pyridone and 4-pyridone species (41 examples) could be obtained in good to excellent yields.

Back to tab navigation

Supplementary files

Article information


Submitted
14 Nov 2019
Accepted
10 Jan 2020
First published
10 Jan 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Paper

Substituent-controlled Chemoselective Synthesis of Multi-substituted Pyridones via One-pot Three-component Cascade Reaction

S. Liu, J. Li, J. Lin, F. Liu, T. Liu and C. Huang, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9OB02456E

Social activity

Search articles by author

Spotlight

Advertisements