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Room temperature iron(ii)-catalyzed radical cyclization of unsaturated oximes with hypervalent iodine reagents

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Abstract

Here, we disclose an iron(II)-catalyzed I–O bond cleavage of Koser's hypervalent iodine reagents (HIRs) that initiated the radical cyclization of unsaturated oximes at room temperature. This strategy is successfully applied for the construction of the isoxazoline backbone in an efficient manner. In particular, the direct introduction of a TsO group into products facilitates their late-stage transformations in organic synthesis.

Graphical abstract: Room temperature iron(ii)-catalyzed radical cyclization of unsaturated oximes with hypervalent iodine reagents

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Article information


Submitted
10 Nov 2019
Accepted
18 Dec 2019
First published
19 Dec 2019

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Room temperature iron(II)-catalyzed radical cyclization of unsaturated oximes with hypervalent iodine reagents

S. Yang, H. Li, P. Li, J. Yang and L. Wang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02424G

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