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Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity

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Abstract

Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans. A plausible biogenetic pathway for eupulcherol A (1) was also proposed.

Graphical abstract: Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity

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Publication details

The article was received on 29 Oct 2019, accepted on 18 Nov 2019 and first published on 19 Nov 2019


Article type: Paper
DOI: 10.1039/C9OB02334H
Org. Biomol. Chem., 2020, Advance Article

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    Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity

    C. Yu, R. Wang, F. Qi, P. Su, Y. Yu, B. Li, Y. Zhao, D. Zhi, Z. Zhang and D. Fei, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02334H

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