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Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT)

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Abstract

Prenylation increases the bioactivity of flavonoids. Herein, we report the first examples of regioselective enzymatic geranylation of biflavonoids using Aspergillus terreus aromatic prenyltransferase (AtaPT). For biflavonoids 1–3 dimerized through a diphenyl linkage, geranylation occurs at the hydrogen bond involving C5′′–OH group, which is less chemically accessible than other OH groups in the molecule. This study would be referential for developing green synthetic solutions for prenylated biflavonoids.

Graphical abstract: Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT)

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Publication details

The article was received on 23 Oct 2019, accepted on 12 Nov 2019 and first published on 20 Nov 2019


Article type: Communication
DOI: 10.1039/C9OB02296A
Org. Biomol. Chem., 2020, Advance Article

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    Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT)

    K. Xu, C. Yang, Y. Xu, D. Li, S. Bao, Z. Zou, F. Kang, G. Tan, S. Li and X. Yu, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02296A

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