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Issue 2, 2020
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Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene

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Abstract

Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx4mc) in complex with proteins. Two crystal structures of sclx4mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx8 and sclx6 but not with sclx4, suggesting that the ligand charge is a determining factor.

Graphical abstract: Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene

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Article information


Submitted
21 Oct 2019
Accepted
03 Dec 2019
First published
03 Dec 2019

Org. Biomol. Chem., 2020,18, 211-214
Article type
Communication

Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene

J. M. Alex, G. Brancatelli, S. Volpi, C. Bonaccorso, A. Casnati, S. Geremia and P. B. Crowley, Org. Biomol. Chem., 2020, 18, 211
DOI: 10.1039/C9OB02275A

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