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Issue 4, 2020
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Complexation of 5-aminovaleric acid zwitterions in aqueous/methanol solution by heterotopic tri-cationic receptors

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Abstract

Heterotopic tri-cationic receptors based on 4,10,16-triaza-18-crown-6 are capable of efficient and selective binding of the zwitterionic form of 5-aminovaleric acid (5-AVA) in aqueous/methanol solution. The cooperative participation of both cation and anion binding domains of this receptor in 5-AVA complexation was established by 1H NMR experiments and DFT calculations. Heterotopic receptors and fluorescein were used for the preparation of indicator displacement assay and this assembly was applied to selective optical sensing of 5-aminovaleric acid.

Graphical abstract: Complexation of 5-aminovaleric acid zwitterions in aqueous/methanol solution by heterotopic tri-cationic receptors

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Article information


Submitted
16 Oct 2019
Accepted
19 Dec 2019
First published
19 Dec 2019

Org. Biomol. Chem., 2020,18, 694-699
Article type
Paper

Complexation of 5-aminovaleric acid zwitterions in aqueous/methanol solution by heterotopic tri-cationic receptors

W. Walczak, M. Zakrzewski, G. Cichowicz and P. Piątek, Org. Biomol. Chem., 2020, 18, 694
DOI: 10.1039/C9OB02234A

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