Jump to main content
Jump to site search


Peptide precursors that acquire denatured collagen-hybridizing ability by O-to-N acyl migration at physiological pH

Abstract

Here, we report peptide probes with either single or cyclic double stranded collagen-like sequences that spontaneously acquire collagen-hybridizing ability at physiological pH. These peptides have ester bonds derived from O-acyl isopeptide units that are converted to amide bonds via intramolecular O-to-N acyl migration by a pH shift. The peptides that do not require pre-treatment for disassembly will be useful as prodrugs in theranostic treatments targeting unfolded collagen.

Back to tab navigation

Supplementary files

Article information


Submitted
03 Oct 2019
Accepted
24 Mar 2020
First published
25 Mar 2020

Org. Biomol. Chem., 2020, Accepted Manuscript
Article type
Communication

Peptide precursors that acquire denatured collagen-hybridizing ability by O-to-N acyl migration at physiological pH

S. Kanai, K. Machida, R. Masuda and T. Koide, Org. Biomol. Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9OB02136A

Social activity

Search articles by author

Spotlight

Advertisements