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Issue 48, 2020
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Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment

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Abstract

At present, cancer is obviously a major threat to human health worldwide. Accurate diagnosis and treatment are in great demand and have become an effective method to alleviate the development of cancer and improve the survival rate of patients. A large number of theranostic probes that combine diagnosis and treatment methods have been developed as promising tools for tumor precision medicine. Among them, fluorescent theranostic probes have developed rapidly in the frontier research field of precision medicine with their real time, low toxicity, and high-resolution merit. Therefore, this review focuses on recent advances in the development of fluorescent theranostic probes, as well as their applications for cancer diagnosis and treatment. Initially, small-molecule fluorescent theranostic probes mainly including tumor microenvironment-responsive fluorescent prodrugs and phototherapeutic probes were introduced. Subsequently, nanocomposite probes are expounded based on four types of nano-fluorescent particles combining different therapies (chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, etc.). Then, the capsule-type “all in one” probes, which occupy an important position in theranostic probes, are summarized according to the surface carrier type. This review aims to present a comprehensive guide for researchers in the field of tumor-related theranostic probe design and development.

Graphical abstract: Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment

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Article information


Submitted
24 Sep 2020
Accepted
15 Nov 2020
First published
16 Nov 2020

Nanoscale, 2020,12, 24311-24330
Article type
Review Article

Research advances in integrated theranostic probes for tumor fluorescence visualization and treatment

J. Xing, Q. Gong, O. U. Akakuru, C. Liu, R. Zou and A. Wu, Nanoscale, 2020, 12, 24311
DOI: 10.1039/D0NR06867E

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