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Issue 46, 2020
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FRACTAL: Signal amplification of immunofluorescence via cyclic staining of target molecules

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Abstract

In this article, we demonstrate fluorescent signal amplification via cyclic staining of target molecules (FRACTAL), a technique that can amplify the signal intensity of immunofluorescence staining more than nine-fold via simple cyclic staining of secondary antibodies. We also show that FRACTAL is compatible with four-color imaging and expansion microscopy imaging.

Graphical abstract: FRACTAL: Signal amplification of immunofluorescence via cyclic staining of target molecules

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Article information


Submitted
06 Aug 2020
Accepted
28 Oct 2020
First published
13 Nov 2020

Nanoscale, 2020,12, 23506-23513
Article type
Communication

FRACTAL: Signal amplification of immunofluorescence via cyclic staining of target molecules

Y. Cho, J. Seo, Y. Sim, J. Chung, C. E. Park, C. G. Park, D. Kim and J. Chang, Nanoscale, 2020, 12, 23506
DOI: 10.1039/D0NR05800A

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