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Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

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Abstract

Hypoxia, as a typical factor in a tumor microenvironment, plays a vital role in tumor treatment resistance, tumor invasion and migration. Hypoxia inducible factor (HIF), as the vital response element of hypoxia, mediates these untoward effects through a series of downstream reactions. Cancer treatments such as photodynamic therapy (PDT), radiotherapy (RT) and chemotherapy are severely hindered by hypoxia and HIF, back, however, could be intelligently manipulated through nanocomposite materials for their great potentiality to combine different functions. Herein, we reviewed the smart strategies in emerging research studies to overcome hypoxia toward the enhancement of tumor therapy.

Graphical abstract: Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

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Article information


Submitted
24 Jul 2020
Accepted
26 Sep 2020
First published
28 Sep 2020

Nanoscale, 2020, Advance Article
Article type
Review Article

Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

M. Xu, P. Wang, S. Sun, L. Gao, L. Sun, L. Zhang, J. Zhang, S. Wang and X. Liang, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR05501H

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