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Ce6-Conjugated and Polydopamine-Coated Gold Nanostars with Enhanced Photoacoustic Imaging and Photothermal/Photodynamic Therapy to Inhibit Lung Metastasis of Breast Cancer

Abstract

Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (1O2) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated a considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer.

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Article information


Submitted
19 Jul 2020
Accepted
06 Oct 2020
First published
07 Oct 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Ce6-Conjugated and Polydopamine-Coated Gold Nanostars with Enhanced Photoacoustic Imaging and Photothermal/Photodynamic Therapy to Inhibit Lung Metastasis of Breast Cancer

Z. Li, F. Yang, D. Wu, Y. Liu, Y. Gao, H. Lian, H. Zhang, Z. Yin, A. Wu and L. Zeng, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR05386D

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