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Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

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Abstract

Novel conjugated carbon dots (CDs) were synthesized as two-photon active photosensitisers to unleash lethal reactive oxygen species (ROS) for nucleus-targeting photodynamic therapy (PDT). To enhance the therapeutic efficiency and preclude non-specific CD uptake, we employed a combination of folic acid and curcumin for two-photon NIR-triggered ROS generation and enhanced internalization in the nucleus. Consequently, enhanced destruction of cancer cells occurred by directly attacking the DNA. The intrinsic ROS generation and nucleus-targeting ability of CDs introduced multifunctional two-photon active nanoprobes within a single platform for enhanced PDT in oral cancer theranostics.

Graphical abstract: Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

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Supplementary files

Article information


Submitted
13 Jul 2020
Accepted
10 Sep 2020
First published
18 Sep 2020

Nanoscale, 2020, Advance Article
Article type
Communication

Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

A. Nasrin, M. Hassan and V. G. Gomes, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR05210H

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