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Issue 40, 2020
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Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for Staphylococcus aureus

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Abstract

The propensity of broad-spectrum antibiotics to indiscriminately kill both pathogenic and beneficial bacteria has a profound impact on the spread of resistance across multiple bacterial species. Alternative approaches that narrow antibacterial specificity towards desired pathogenic bacterial population are of great interest. Here, we report an enzyme-responsive antibiotic-loaded nanoassembly strategy for narrow delivery of otherwise broad-spectrum antibiotics. We specifically target Staphylococcus aureus (S. aureus), an important blood pathogen that secretes PC1 β-lactamases. Our nanoassemblies selectively eradicate S. aureus grown in vitro with other bacteria, highlighting its potential capability in targeting the desired pathogenic bacterial population.

Graphical abstract: Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for Staphylococcus aureus

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Supplementary files

Article information


Submitted
29 Jun 2020
Accepted
24 Sep 2020
First published
24 Sep 2020

Nanoscale, 2020,12, 20693-20698
Article type
Paper

Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for Staphylococcus aureus

T. M. Koyasseril-Yehiya, A. García-Heredia, F. Anson, P. Rangadurai, M. S. Siegrist and S. Thayumanavan, Nanoscale, 2020, 12, 20693
DOI: 10.1039/D0NR04886K

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