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A Minireview on Multiparameter-activated Nanodevices for Cancer Imaging and Therapy


Tumor microenvironment (TME)-responsive nanodevices are essential tools for cancer imaging and therapy. Exploiting the advantages of molecular engineering, nanodevices are springing up for biomedical applications. In order to reach targeted cancer areas, activated nanodevices first respond to the tumor microenvironment and then serve as an actuator for sensing, imaging and therapy. Most nanodevices depend on a single parameter as an input for their downstream activation, potentially leading to inaccurate diagnostic results and poor therapeutic outcomes. However, in the TME, some biomarkers are crosslinked, and such correlated biomarkers are potentially useful for cancer imaging and theranostic applications. Based on this phenomenon, researchers have developed approaches to construct multiparameter-activated nanodevices (MANs) to improve accuracy. This minireview summarizes recent advances in the development of MANs for cancer imaging including fluorescence imaging, photoacoustic imaging, magnetic resonance imaging and computed tomography imaging, as well as cancer therapy including radiotherapy, chemotherapy, photoinduced therapy and immunotherapy. We highlight different approaches to improve the specificity and precision of cancer imaging and therapy. In the future, MANs show promise for clinical work in multimodal diagnosis and therapeutics.

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Article information

28 May 2020
11 Sep 2020
First published
15 Sep 2020

Nanoscale, 2020, Accepted Manuscript
Article type

A Minireview on Multiparameter-activated Nanodevices for Cancer Imaging and Therapy

H. Bai, R. Peng, D. Wang, M. Sawyer, T. Fu, C. Cui and W. Tan, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR04080K

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