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Issue 27, 2020
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Standardizing luminescence nanothermometry for biomedical applications

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Luminescence nanothermometry enables accurate, remote, and all-optically-based thermal sensing. Notwithstanding its fast development, there are serious obstacles hindering reproducibility and reliable quantitative assessment of nanothermometers, which impede the intentional design, optimization and use of these sensors. These issues include ambiguities or absence of established universal rules for quantitative evaluation, incorrect assumptions about the mechanisms behind the thermal response of the sensors as well as the dependence of the nanothermometers readout on external conditions and host materials themselves. In this perspective article, we discuss these problems and propose a series of standardization guidelines to be followed. This critical discourse constitutes the first required step towards the ubiquitous acceptance, by the scientific community, of luminescence thermometry as a reliable tool for remote temperature determination in numerous practical biomedical implementations.

Graphical abstract: Standardizing luminescence nanothermometry for biomedical applications

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Article information

07 May 2020
30 Jun 2020
First published
30 Jun 2020

Nanoscale, 2020,12, 14405-14421
Article type
Review Article

Standardizing luminescence nanothermometry for biomedical applications

A. Bednarkiewicz, L. Marciniak, L. D. Carlos and D. Jaque, Nanoscale, 2020, 12, 14405
DOI: 10.1039/D0NR03568H

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