Issue 32, 2020
From the journal:

Nanoscale

Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers†

Mansoore Esmaili, ORCID logo a   Chanelle J. Brown,b   Rustem Shaykhutdinov,a   Claudia Acevedo-Morantes,c   Yong Liang Wang,c   Holger Wille, ORCID logo c   Richard D. Gandour, ORCID logo *b   S. Richard Turnerb  and  Michael Overduin ORCID logo *a  

* Corresponding authors

a Department of Biochemistry, University of Alberta, Edmonton, Canada
E-mail: Overduin@ualberta.ca

b Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, USA
E-mail: gandour@vt.edu

c Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada

Abstract

Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ∼20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.

Graphical abstract: Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers

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Article information

DOI
https://doi.org/10.1039/D0NR03435E
Article type
Communication
Submitted
02 May 2020
Accepted
11 Jul 2020
First published
11 Aug 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2020,12, 16705-16709

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Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers

M. Esmaili, C. J. Brown, R. Shaykhutdinov, C. Acevedo-Morantes, Y. L. Wang, H. Wille, R. D. Gandour, S. R. Turner and M. Overduin, Nanoscale, 2020, 12, 16705 DOI: 10.1039/D0NR03435E

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