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Issue 25, 2020
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Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy

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Abstract

Tumor hypoxia compromises the effects of photodynamic therapy that consumes oxygen in the therapeutic process. Herein, a platinum (Pt)-carbon-integrated nanozyme with favorable catalase-like activity and photosensitizing properties was successfully constructed by immobilizing an ultrasmall Pt nanozyme into a MOF-derived carbon nanozyme through an in situ reduction strategy. The integration of a Pt nanozyme significantly improves the catalase activity of a carbon nanozyme that can effectively catalyze the decomposition of endogenous hydrogen peroxide to produce oxygen to improve the effects of photodynamic therapy. In addition, the integration of a Pt nanozyme also enhances the intrinsic photothermal performance of a carbon nanozyme. Combining the improved catalase-like activity with the enhanced photothermal properties together, the Pt-carbon nanozyme exhibits remarkable tumor inhibition ability in vivo. Thus, utilizing the enzymatic activity and photothermal/photosensitizing properties of nanozymes has great potential to overcome the limitations of traditional therapeutic strategies, and could inspire new directions for nanozyme-based biomedical applications.

Graphical abstract: Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy

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Supplementary files

Article information


Submitted
09 Apr 2020
Accepted
28 May 2020
First published
29 May 2020

Nanoscale, 2020,12, 13548-13557
Article type
Paper

Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy

Y. Yang, D. Zhu, Y. Liu, B. Jiang, W. Jiang, X. Yan and K. Fan, Nanoscale, 2020, 12, 13548
DOI: 10.1039/D0NR02800B

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