Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery

Author affiliations

Abstract

Angiogenesis is an irreplaceable therapeutic cancer target, where anti-angiogenesis are drugs that are limited by their hydrophobicity and low therapeutic effects. What is more, the long-term shutdown of tumor blood vessel density also aggravates hypoxia and causes immunosuppression in the tumor microenvironment (TME). In order to solve these shortcomings, we developed a single therapeutic agent based on a bovine serum albumin nanocarrier that can co-deliver the anti-angiogenic drug Sorafenib (“S”) and the photosensitizer Ce6 (“C”) along with a molecular oxygen supply based on MnO2 (“M”) as a convenient one-pot formulated nanoscale agent (SCM@BSA). Compared with anti-angiogenesis monotherapy, SCM@BSA can not only improve upon the solubility and therapeutic effects of anti-angiogenesis agents, but it also reshapes the immunosuppressive TME during anti-angiogenic therapy. Together, these results point out that SCM@BSA synthesized via a very simple method can solve the shortcomings usually experienced during long-term anti-angiogenic therapy.

Graphical abstract: Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery

Back to tab navigation

Supplementary files

Article information


Submitted
07 Apr 2020
Accepted
19 Jun 2020
First published
23 Jun 2020

Nanoscale, 2020, Advance Article
Article type
Paper

Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery

Q. He, Z. Zhang, H. Liu, Z. Tuo, J. Zhou, Y. Hu, Y. Sun, C. Wan, Z. Xu, J. F. Lovell, D. Hu, K. Yang and H. Jin, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR02750B

Social activity

Search articles by author

Spotlight

Advertisements