Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Single-wavelength phototheranostics for colon cancer via the thiolytic reaction

Author affiliations

Abstract

It's a huge challenge to develop effective nanosystems that combine the capabilities of diagnoses and therapies together for colon cancer in the clinic. Herein, we constructed a far-red absorbing phototheranostic nanosystem (FR-H2S) based on the thiolytic reaction of a dinitrophenyl modified phototheranostic prodrug and over-expressed H2S in colon cancer sites for precise imaging-guided phototherapy. FR-H2S with a BODIPY core not only could work as an imaging probe for diagnosis but also act as a phototherapeutic agent for cancer treatment under a single FR laser source (650 nm). FR-H2S exhibited a gradually enhanced fluorescence emission for precise diagnosis of H2S-rich colon tumor sites. After entering tumor cells, FR-H2S could generate abundant 1O2 and heat for phototherapies timely by using the same laser source (650 nm). We believe that this precise imaging-guided phototheranostic nanosystem could provide a promising approach to colon cancer with minimal damage.

Graphical abstract: Single-wavelength phototheranostics for colon cancer via the thiolytic reaction

Back to tab navigation

Supplementary files

Article information


Submitted
25 Mar 2020
Accepted
05 May 2020
First published
07 May 2020

Nanoscale, 2020, Advance Article
Article type
Paper

Single-wavelength phototheranostics for colon cancer via the thiolytic reaction

Y. Zhu, C. Chen, Q. Wu, G. Yang, Z. Liu, E. Hao, H. Cao, Y. Gao and W. Zhang, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR02393K

Social activity

Search articles by author

Spotlight

Advertisements