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Single-wavelength phototheranostics for colon cancer via thiolytic reaction

Abstract

It’s a huge challenge to develop effective nanosystems combined the capabilities of diagnoses and therapies together for colon cancer in clinic. Herein, we constructed a far-red absorbing phototheranostic nanosystem (FR-H2S) based on thiolytic reaction of dinitrophenyl modified phototheranostic prodrug and the over-expressed H2S in colon cancer sites for precise imaging-guided phototherapy. FR-H2S with a BODIPY core not only could work as an imaging probe for diagnosis but also act as a phototheraputic agent for cancer treatment under a single FR laser source (650 nm). FR-H2S exhibited a gradually enhanced fluorescence emission for precise diagnosis of H2S-rich colon tumor sites. After entering tumor cells, FR-H2S could generate abundant 1O2 and heat for phototherapies timely by using the same laser source (650 nm). We believe that this precise imaging-guided phototheranostic nanosystem could provide a promising approach to colon cancer with minimal damage.

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Supplementary files

Article information


Submitted
25 Mar 2020
Accepted
05 May 2020
First published
07 May 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Single-wavelength phototheranostics for colon cancer via thiolytic reaction

Y. Zhu, C. Chen, Q. Wu, G. Yang, Z. Liu, E. Hao, H. Cao, Y. Gao and W. Zhang, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR02393K

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