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Self-degrading graphene sheets for tumor therapy

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Abstract

Low biodegradability of graphene derivatives and related health risks are the main limiting factors for their in vivo biomedical applications. Here, we present the synthesis of enzyme-functionalized graphene sheets with self-degrading properties under physiological conditions and their applications in tumor therapy. The synergistic enzyme cascade glucose oxidase and myeloperoxidase are covalently conjugated to the surface of graphene sheets and two-dimensional (2D) platforms are obtained that can produce sodium hypochlorite from glucose. The enzyme-functionalized graphene sheets with up to 289 nm average size are degraded into small pieces (≤40 nm) by incubation under physiological conditions for 24 h. Biodegradable graphene sheets are further loaded with doxorubicin and their ability for tumor therapy is evaluated in vitro and in vivo. The laser-triggered release of doxorubicin in combination with the enzymatic activity of the functionalized graphene sheets results in a synergistic antitumor activity. Taking advantage of their neutrophil-like activity, fast biodegradability, high photo- and chemotherapeutic effects, the novel two-dimensional nanoplatforms can be used for tumor therapeutic applications.

Graphical abstract: Self-degrading graphene sheets for tumor therapy

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Supplementary files

Article information


Submitted
17 Mar 2020
Accepted
20 Jun 2020
First published
26 Jun 2020

Nanoscale, 2020, Advance Article
Article type
Paper

Self-degrading graphene sheets for tumor therapy

I. S. Donskyi, Y. Chen, P. Nickl, G. Guday, H. Qiao, K. Achazi, A. Lippitz, W. E. S. Unger, C. Böttcher, W. Chen, M. Adeli and R. Haag, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR02159H

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