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Issue 38, 2020

Transport of nanoprobes in multicellular spheroids

Author affiliations

Abstract

The efficient delivery of drugs to cells depends on their diffusion through the extracellular matrix (ECM) of tissues. Here we present a study on the diffusion of nanoprobes of radius from 1 nm to over 100 nm in the ECM of spheroids of three cell types (HeLa, MCF-7 and fibroblasts). We quantified the nanoparticle transport in the spheroids’ proliferating zone. We determined the size-dependent viscosity of the ECM. We revealed that nanoobjects up to 10 nm in radius exhibited unobstructed diffusion in the ECM, regardless of the spheroid type. The presented length-scale dependent viscosity profiles for spheroids pave the way for advanced modelling of drug administration through tissues.

Graphical abstract: Transport of nanoprobes in multicellular spheroids

Supplementary files

Article information


Submitted
10 Mar 2020
Accepted
27 Aug 2020
First published
28 Aug 2020

This article is Open Access

Nanoscale, 2020,12, 19880-19887
Article type
Paper

Transport of nanoprobes in multicellular spheroids

M. Pilz, K. Kwapiszewska, T. Kalwarczyk, G. Bubak, D. Nowis and R. Hołyst, Nanoscale, 2020, 12, 19880 DOI: 10.1039/D0NR01986K

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