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Issue 25, 2020
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Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

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Abstract

Tumor-targeted drug carriers are becoming attractive for precise drug delivery in anti-tumor therapy. However, a lot of the reported drug delivery systems are complicatedly designed and their destiny in vivo is beyond our control, which limited their clinical applications. Hence, it is urgently needed to develop spatio-manipulable self-propelled nanosystems for drug delivery in a facile way. Here, we have successfully constructed drug-internalized bacterial swimmers, whose movement can be manually controlled by an external magnetic field (MF). We demonstrate that the swimmers maintain the mobility to align and swim along MF lines. Further studies reveal that the doxorubicin (DOX-) internalized bacterial swimmers are able to navigate toward tumor sites under the guidance of MF, rendering enhanced anti-tumor efficacy compared with that of dead ones and free DOX. Therefore, the MF-guided bacterial swimmers hold great promise for spatio-manipulable drug delivery in precision medicine.

Graphical abstract: Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

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Supplementary files

Article information


Submitted
06 Mar 2020
Accepted
02 Jun 2020
First published
03 Jun 2020

Nanoscale, 2020,12, 13513-13522
Article type
Paper

Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Z. Xiang, G. Jiang, D. Fan, J. Tian, Z. Hu and Q. Fang, Nanoscale, 2020, 12, 13513
DOI: 10.1039/D0NR01892A

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