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Cellular Architecture Response to Aspect Ratio Tunable Nanoarrays

Abstract

Nanoarrays have been emerging as popular nanostructure platforms to investigate both cell behaviors and biological functions, due to the cell architecture respondence to biointerface of nanostructure. Herein, we developed a series of aspect ratio tunable nanoarrays through a metal-assisted chemical etching method. Nanoarrays including nanoneedle, nanopillar, and nanocluster were fabricated with controllable aspect ratio. We found nanostructures with high aspect ratio (>10) induced significant alternations on cell physiological behaviors as surface attachment, architecture deformation, viability, proliferation and motility. Cells on nanostructures with high aspect ratio exhibited reorganized actin stress fibers and vimentin filaments, as well as reduced focal adhesion. This research enlarges diversity of nanostructures on nano-bio interface investigation, provides a new insight for surface-depended architecture of cells, and offers unbiased understanding of factors influencing cell physiology.

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Supplementary files

Article information


Submitted
05 Feb 2020
Accepted
05 May 2020
First published
06 May 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Cellular Architecture Response to Aspect Ratio Tunable Nanoarrays

J. Dai, J. Gong, N. Kong and Y. Yao, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR01003K

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