Integration of Porous Coordination Network and Black Phosphorus Nanosheets for Improved Photodynamic Therapy of Tumor
Selectively attenuating the protection of heat shock protein 90 (HSP90), which is indispensable for the stabilization of essential regulators of cell survival and works as cell guardian under oxidative stress conditions, would be a potential approach to improve the efficiency of cancer therapy. Here, we designed a biodegradable nanoplatform (APCN/BP-FA) based on integration of Zr (IV)-based porphyrinic porous coordination network (PCN) and black phosphorus (BP) sheets for efficient photodynamic therapy (PDT) by enhancing the accumulation of the nanoplatforms in tumor area and attenuating the protection of cancer cells. Owing to the favorable degradability of BP, the nanosystem exhibited accelerating HSP90 inhibitor tanespimycin (17-AAG) release and apparent promotion of the reactive oxygen species (ROS) yield of PCN, as well as expediting the degradation of the PCN-laden BP nanoplatforms. Both in vitro and in vivo results revealed the enlarged amount of ROS and reduced cytoprotection in tumor cells were caused by the nanoplatforms. This strategy may provide a promising method of attenuating the cytoprotection in efficient photodynamic therapy.