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The essential role of osteoclast-derived exosomes in magnetic nanoparticles-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in osteoporosis model

Abstract

The magnetic hydroxyapatite scaffold (MHA) promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitination, ATP and reactive oxygen species, decreased in osteoclast-derived exosomal cargo with MHA stimulation while Rho kinase increased.

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Supplementary files

Article information


Submitted
31 Jan 2020
Accepted
02 Mar 2020
First published
11 Mar 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Communication

The essential role of osteoclast-derived exosomes in magnetic nanoparticles-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in osteoporosis model

Y. Zhu, Z. Li, Y. Zhang, F. Lan, J. He and Y. Wu, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR00867B

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