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Recent Advances in Molecular Imaging of Atherosclerotic Plaques and Thrombosis

Abstract

As the complications of atherosclerosis such as myocardial infarction and stroke are still one of the leading causes of mortality worldwide, the development of new diagnostic tools for the early detections of plaques instability and thrombosis is urgently needed. Advanced molecular imaging probes based on functional nanomaterials in combination with cutting edge imaging techniques, are providing novel and unique tools for monitoring the inflammatory progresses in atherosclerosis. This review focuses on the development of various molecular probes for the diagnostics of plaques and thrombosis in atherosclerosis, along with perspectives of their diagnostic applications in cardiovascular diseases. Specifically, we summarize the biological targets that can be used for the atherosclerosis imaging. Then we mainly describe the emerging molecular imaging techniques based on the utilisation of engineered nanoprobes together with their challenges in clinical translation.

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Article information


Submitted
21 Jan 2020
Accepted
20 Mar 2020
First published
23 Mar 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Review Article

Recent Advances in Molecular Imaging of Atherosclerotic Plaques and Thrombosis

R. Qiao, X. Huang, Y. Qin, Y. Li, T. P. Davis, C. Hagemeyer and M. Gao, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR00599A

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