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In situ construction of a self-assembled AIE probe for tumor hypoxia imaging

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Abstract

This communication reported a hypoxia-responsive fluorescent probe based on the in situ concept, which combines a water-soluble azobenzene containing copolymer with a carbamate linkage and an anionic water-soluble aggregation-induced emission fluorogen (AIEgen) tetraphenylethene (TPE). The water-soluble copolymer can be transformed into a protonated primary amine containing polymer by the reduction of the azo bond and through a 1,6-self elimination cascade reaction under hypoxic conditions. The transition of anionic TPE from the molecular dispersed state to the aggregation state induced by self-assembly with the cationic polymer would lead to an obvious increase in fluorescence according to the AIE characteristics.

Graphical abstract: In situ construction of a self-assembled AIE probe for tumor hypoxia imaging

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Supplementary files

Article information


Submitted
16 Jan 2020
Accepted
13 Mar 2020
First published
16 Mar 2020

Nanoscale, 2020, Advance Article
Article type
Communication

In situ construction of a self-assembled AIE probe for tumor hypoxia imaging

T. Xue, K. Shao, J. Xiang, X. Pan, Z. Zhu and Y. He, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR00444H

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