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Issue 20, 2020
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A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

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Abstract

A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

Graphical abstract: A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

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Article information


Submitted
10 Jan 2020
Accepted
28 Feb 2020
First published
02 Mar 2020

Nanoscale, 2020,12, 10939-10943
Article type
Communication

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

D. Zhao, G. Yang, Q. Liu, W. Liu, Y. Weng, Y. Zhao, F. Qu, L. Li and Y. Huang, Nanoscale, 2020, 12, 10939
DOI: 10.1039/D0NR00301H

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