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An NIR-II/MR dual modal nanoprobe for liver cancer imaging

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Abstract

Hepatocellular carcinoma (HCC) is a malignancy of the liver worldwide and surgical resection remains the most effective treatment. However, it is still a great challenge to locate small lesions and define the border of diffused HCC even with the help of preoperative imaging examination. Here, we reported a rare-earth-doped nanoparticle NaGdF4:Nd 5%@NaGdF4@Lips (named Gd-REs@Lips), which simultaneously performed powerful functions in both magnetic resonance imaging (MRI) and second near-infrared fluorescence window imaging (NIR-II, 1000–1700 nm). Imaging studies on orthotopic models with xenografts established from HCC patients indicated that Gd-REs@Lips efficiently worked as a T2-weighted imaging contrast agent to increase the signal intensity difference between liver cancer tissues and surrounding normal liver tissues on MRI, and it can also serve as a negative NIR-II imaging contrast enabling the precise detection of liver cancer. More importantly, benefiting from the high sensitivity of NIR-II imaging, Gd-REs@Lips allowed the visualization of tiny metastasis lesions (2 mm) on the liver surface. It is expected that the dual NIR-II/MRI modal nanoprobe developed holds high potential to fill the gap between the preoperative imaging detection of cancer lesions and intra-operative guidance, and it further brings new opportunities to address HCC-related medical challenges.

Graphical abstract: An NIR-II/MR dual modal nanoprobe for liver cancer imaging

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Article information


Submitted
04 Jan 2020
Accepted
17 Apr 2020
First published
24 Apr 2020

Nanoscale, 2020, Advance Article
Article type
Paper

An NIR-II/MR dual modal nanoprobe for liver cancer imaging

Y. Ren, S. He, L. Huttad, M. Chua, S. K. So, Q. Guo and Z. Cheng, Nanoscale, 2020, Advance Article , DOI: 10.1039/D0NR00075B

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