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A nano-photosensitizer based on covalent organic framework nanosheets with high loading and therapeutic efficacy

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Abstract

Photooxidation provides a promising strategy for photocatalysis, photodynamic therapy, and environmental protection. Unfortunately, most organic photosensitizers possess weak hydrophilicity and a π–π conjugated structure, leading to singlet oxygen self-quenching, poor loadability and therefore unsatisfactory photooxidation efficiency. Thus, dispersion of these photosensitizers within a two-dimensional porous covalent organic framework has become a feasible strategy to hinder their self-aggregation and augment their loading capacity. Here, we report a phthalocyanine-based photosensitizer loaded on covalent organic framework nanosheets. This nano-photosensitizer exhibits highly dispersed organic fluorescent phthalocyanines and a high loading capacity. The fabricated nanosheets restrict self-aggregation of photosensitizer molecules and enhance the photooxidation activity, which may offer a new paradigm for photooxidation and its multiple applications.

Graphical abstract: A nano-photosensitizer based on covalent organic framework nanosheets with high loading and therapeutic efficacy

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Article information


Submitted
23 Dec 2019
Accepted
08 Feb 2020
First published
09 Mar 2020

Nanoscale, 2020, Advance Article
Article type
Paper

A nano-photosensitizer based on covalent organic framework nanosheets with high loading and therapeutic efficacy

X. Tong, S. Gan, J. Wu, Y. Hu and A. Yuan, Nanoscale, 2020, Advance Article , DOI: 10.1039/C9NR10787H

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