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Targeted Nanocarriers Based on Iodinated-Cyanine Dyes as Immunomodulators for Synergistic Phototherapy

Abstract

Photodynamic therapy (PDT), as one of the most powerful photo-therapeutic strategies for cancer treatment with minimum invasiveness, can effectively damage local tumor cells and significantly induce systemic antitumor immunity. However, current nanotechnology-assisted PDT-immunomodulators has either poor penetration for deep tumors or low singlet oxygen generation. Herein, we construct a novel theranostic nanocarrier (HA-PEG-CyI, HPC) by inducing the self-assembly of PEGylated CyI and attaching the ligand HA to its surface. The prepared HPC can be used as an ideal PDT-immunomodulator for synergistic cancer therapy. CyI is an iodinated-cyanine dye with enhanced singlet oxygen generation ability as well as excellent photo-to-photothermal and near-infrared fluorescence imaging properties. Under 808nm laser irradiation, the prepared HPC can generate both reactive oxygen species (ROS) and elevate temperature which can subsequently result in apoptosis and necrosis at tumor site. Moreover, the HPC-induced cell death can generate a series of acute inflammatory reaction, leading to systemic immunity induction and secondary death of tumor cells, which further results in reducing tumor recurrence. In vitro and in vivo results show that HPC can enhance the tumor targeting efficacy, generate ROS efficiently and perform high temperature response under NIR irradiation, which working together can activate immune responses for synergistic phototherapy on tumor cells. Accordingly, the proposed multi-functional nanocarrier HPC represent an important advance in PDT and can be used as a superior cancer treatment strategy with great promises for clinical applications.

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Supplementary files

Article information


Submitted
18 Dec 2019
Accepted
19 Mar 2020
First published
20 Mar 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Paper

Targeted Nanocarriers Based on Iodinated-Cyanine Dyes as Immunomodulators for Synergistic Phototherapy

J. Chi, Q. Ma, Z. Shen, C. Ma, W. Zhu, S. Han, Y. Liang, J. Cao and Y. Sun, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR10674J

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