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Issue 13, 2020
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Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

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Abstract

The study reported here concerns the preparation of a novel graphene-diaminotriazine (G-DAT) nanocomposite hydrogel for application in the drug delivery field. The hybrid nature of this material is founded on two key elements: the presence of the DAT backbone induced the formation of hydrophobic regions that allowed efficient loading of a series of drugs of increasing hydrophobicity (Metronidazole, Benzocaine, Ibuprofen, Naproxen and Imipramine), while simultaneously endowing swelling-induced pH-responsiveness to the hydrogel. Additionally, the incorporation of graphene was found to interfere with these hydrophobic domains through favourable non-covalent interactions, thus leading to the partial disruption of these aggregates. As a consequence, graphene facilitated and enhanced the release of model hydrophobic drug Imipramine in a synergistic manner with the pH trigger, and increased the swelling capacities and improved mechanical performance. This hybrid hydrogel can therefore be envisaged as a proof-of-concept system for the release of hydrophobic compounds in the field of drug delivery.

Graphical abstract: Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

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Supplementary files

Article information


Submitted
14 Dec 2019
Accepted
26 Feb 2020
First published
18 Mar 2020

This article is Open Access

Nanoscale, 2020,12, 7072-7081
Article type
Paper

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

J. Leganés, A. Sánchez-Migallón, S. Merino and E. Vázquez, Nanoscale, 2020, 12, 7072
DOI: 10.1039/C9NR10588C

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