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Direct Silica Coating of Drug Crystals for Ultra-high Loading

Abstract

To push the limit of synthetic control, we create a thin layer (5 nm) of silica on the surface of drug nanocrystals, achieving a loading content (88%) that approaches the theoretic limit. The uniform silica shell provides a tailored diffusion barrier for controlled drug release. The method can be generally applied to 11 organic crystals, including 4 drugs.

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Article information


Submitted
03 Dec 2019
Accepted
09 Feb 2020
First published
10 Feb 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Communication

Direct Silica Coating of Drug Crystals for Ultra-high Loading

N. Wang, W. Zhou, M. Yan, M. Zhang, H. Wang and H. Chen, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR10225F

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